Rheumatoid Arthritis

Gene Therapy Inhibits Nuclear Translocation of Nuclear Factor Kappa B

Published in Gene Therapy Weekly, July 13th, 2000

Gene therapy for rheumatoid arthritis may be one step closer, suggests research from the United States.

"Tumor necrosis factor alpha (TNF alpha) increases the survival and proliferation of human rheumatoid arthritis (RA) cell lines," stated H.G. Zhang and colleagues from the University of Alabama. "These experiments were designed to determine if inhibition of nuclear factor KB (NF-KB) nuclear translocation leads to increased apoptosis of TNF alpha-treated human RA cell lines.

"We constructed an inhibitor of nuclear factor kappa B (I kappa B) dominant-negative adenovirus (Ad-CMVI kappa B-DN) and an X-linked inhibitor of apoptosis (XIAP) antisense...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Gene Therapy Weekly

Source: Gene Therapy Weekly (2000-07-13)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry