Published in Gene Therapy Weekly, August 3rd, 2000
A U.S. Investigational New Drug Application (IND) for this compound was filed in May 2000. Additional international regulatory filings for Phase I multi-dose trials in Canada and Belgium are planned.
A key function of the Ras pathway is cell proliferation. In normal cell proliferation, when the Ras pathway is activated, or "on," it sends a signal telling the cell to grow and divide. When a gene in the pathway is mutated, the signal may not turn "off," causing...
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