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Parkinson's Disease

Gene Therapy Effective in Animal Studies

Published in Gene Therapy Weekly, August 3rd, 2000

An international team of scientists has reversed some of the effects of Parkinson's disease in rats with a drug-induced form of the progressive movement disorder.

By inserting corrective genes into the brain, researchers were able to trigger the regeneration of a critical bundle of nerve fibers. The new growth was linked to significant - but not complete - recovery of the animals' ability to use their paws spontaneously, said Ronald J. Mandel, a University of Florida scientist who was part of the team and a co-author of a recent Journal of Neuroscience article describing the research.

"For a long time, we had known that if the cells that...

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