Hepatocellular Carcinoma

Lipiodol/Adenovirus Gene Therapy Vector Interactions Evaluated in vivo

Published in Gene Therapy Weekly, August 10th, 2000

Researchers in Japan have evaluated the interactions between Lipiodol and adenovirus vector for gene delivery to hepatocellular carcinoma (HCC) cells both in vitro and in vivo.

"In gene therapy for cancer, gene targeting of cancer cells is essential. HCC is a hypervascular tumor fed by tumor-specific arteries. The delivery of anticancer drugs through such arteries is known as transarterial embolism (TAE)," explained H. Shiba and colleagues from the Jikei University School of Medicine, Japan.

"We speculated that Lipiodol could be used to efficiently deliver a gene to HCC. However, Lipiodol could influence vector infection or transgene expression. ...

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Source: Gene Therapy Weekly (2000-08-10)

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