Drug Interactions
Methimazole Increases Impact of P450 Suicide Gene Therapy
Published in Gene Therapy Weekly, September 14th, 2000
"The effect of the antithyroid drug MMI on cytochrome P450/P450 reductase-dependent activation of the anti-cancer prodrug cyclophosphamide (CPA) was investigated in a rat model of P450 prodrug activation-based cancer gene therapy," wrote Z.Q. Huang and colleagues, Boston University, Massachusetts. "MMI treatment decreased the expression of hepatic P450 reductase by similar to 75% but did not alter P450 reductase levels in a 9L gliosarcoma growing in vivo as a subcutaneous solid tumor."
The researchers observed that MMI...
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Source: Gene Therapy Weekly (2000-09-14)
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