Published in Gene Therapy Weekly, September 14th, 2000
"The effect of the antithyroid drug MMI on cytochrome P450/P450 reductase-dependent activation of the anti-cancer prodrug cyclophosphamide (CPA) was investigated in a rat model of P450 prodrug activation-based cancer gene therapy," wrote Z.Q. Huang and colleagues, Boston University, Massachusetts. "MMI treatment decreased the expression of hepatic P450 reductase by similar to 75% but did not alter P450 reductase levels in a 9L gliosarcoma growing in vivo as a subcutaneous solid tumor."
The researchers observed that MMI...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Gene Therapy Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.