Published in Gene Therapy Weekly, September 21st, 2000
"Conventional treatments of human gliomas have achieved limited success," stated Frederick F. Lang and colleagues from the M.D. Anderson Cancer Center, Texas, the University of California, and the North American Brain Tumor Consortium.
"Preclinical studies have suggested that transfer of the p53 gene using an adenovirus vector (Ad-p53, RPR/INGN 201) may be clinically applicable in gliomas. Consequently, a Phase I clinical trial of Ad-p53 for recurrent gliomas was undertaken in order to...
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