HIV Vaccines

Oral DNA Vaccine Induces Mucosal and Systemic Immune Responses

Published in Gene Therapy Weekly, September 28th, 2000

Researchers in Japan, Poland, and the United States collaborated on designing an orally-delivered DNA vaccine that produces mucosal and systemic immune responses against HIV.

Discussing their study at the 14th European Immunology Meeting, held September 23-27, 2000, in Poznan, Poland, presenting author Andrzej Wierzbicki and colleagues said: "We described induction of HIV envelope (env)-specific systemic and mucosal immune responses by oral vaccination of BALB/c mice with env-encoded plasmid DNA encapsulated in poly(DL-lactide-co-glycolide) (PLG) microparticles. We demonstrated that intragastric administration of encapsulated plasmid DNA resulted in transduced...

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Source: Gene Therapy Weekly (2000-09-28)

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