HIV Vaccines

HIV-1 Plasmid Antigens and IL-12-Expressing Plasmids Key Components

Published in Gene Therapy Weekly, November 2nd, 2000

In a recent study, researchers in the United States observed transient declines in viral load in HIV-1 infected chimpanzees vaccinated with HIV-1 DNA vaccines.

J.D. Boyer and colleagues, University of Pennsylvania, assessed "HIV-1 DNA vaccination and co-immunization with interleukin (IL)-12 and IL-10 as immunotherapy in the HIV-1 infected chimpanzee model system. Four chimpanzees that were infected with HIV-1-IIIB for longer than four years and remained symptom-free were immunized with HIV-1 plasmid vaccines."

The researchers vaccinated two chimpanzees with DNA plasmids encoding env/rev and gag/pol along with a plasmid that encoded...

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Source: Gene Therapy Weekly (2000-11-02)

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