Arrhythmia

Gene Therapy to Calm Pigs' Out-of-Sync Hearts Reported

Published in Gene Therapy Weekly, December 21st, 2000

Scientists at Johns Hopkins University have developed a gene therapy that, within a week, quells abnormal rhythms in pig hearts, the animal hearts most similar to human.

It's believed to be the first use of gene therapy for cardiac arrhythmias, the researchers say, and one with "a strong possibility" of transfer to human heart disease.

"We've effectively treated an arhythmia in a well-tested animal model, using genes delivered by routine catheter methods, no open chest, no contrivances, just simple modifications of existing technology," said Eduardo Marban, MD, PhD. "This is the first proof-of-concept work, and the first clear step toward a...

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Source: Gene Therapy Weekly (2000-12-21)

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