Cervical Cancer
Genetic Immunization Using Recombinant Alphavirus Vector of HPV Proteins Could be Therapeutic, Prophylactic
Published in Gene Therapy Weekly, January 11th, 2001
Researchers in The Netherlands created a recombinant Semliki Forest virus (SFV) vector that expresses the human papillomavirus (HPV) proteins, E6 and E7. Expression of E6 and E7, they explained, is key to the transforming potential of HPV-16 and HPV-18, strains linked to development of cervical cancer via infection of genital epithelial cells.
"Since the expression of E6 and E7 is selectively maintained in premalignant and malignant cervical lesions,...
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Source: Gene Therapy Weekly (2001-01-11)
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