Neuropathic Pain

Rat Studies Illuminate Potential Therapy

Published in Gene Therapy Weekly, February 15th, 2001

- by Maryclaire Lindgren, staff medical writer -- Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) reduces pain due to nerve injury.

Nerve injury can induce refractory pain wherein even opioids are not effective. M.E. Fundytus, of McGill University in Canada, and associates, looking to find a means to ease this type of pain, evaluated the effects of antisense oligonucleotide knockdown of mGluR(1) in nerve-injured rats. Their results shed light on a possible pain therapy.

"These results suggest that activity at mGluR(1) contributes to neuropathic pain through interactions with spinal [N-methyl-D-aspartate] receptors and [protein...

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Source: Gene Therapy Weekly (2001-02-15)

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