Published in Gene Therapy Weekly, February 15th, 2001
Nerve injury can induce refractory pain wherein even opioids are not effective. M.E. Fundytus, of McGill University in Canada, and associates, looking to find a means to ease this type of pain, evaluated the effects of antisense oligonucleotide knockdown of mGluR(1) in nerve-injured rats. Their results shed light on a possible pain therapy.
"These results suggest that activity at mGluR(1) contributes to neuropathic pain through interactions with spinal [N-methyl-D-aspartate] receptors and [protein...
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