Gynecology

In vivo Gene Transfer to Epithelium Possible

Published in Gene Therapy Weekly, February 15th, 2001

- by Michelle Marble, staff medical writer -- Researchers in Spain successfully transfected the female reproductive tract of mice using DNA/lipsome complexes.

"Mouse female genital tract was transfected in vivo using the beta-galactosidase reporter gene," stated N. Relloso and colleagues from Madrid. "To transfect the female tract, DNA/liposome complexes were injected through the infundibulum of the oviducts of adult, immature, and pseudopregnant females. Females which were in different stages of the ovarian cycle were also employed."

Relloso et al. published the results of their study in the journal Molecular Human Reproduction ("In vivo...

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Source: Gene Therapy Weekly (2001-02-15)

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