Melanoma

Combination Therapy Approach Induces Long-Term Antitumor Immunity

Published in Gene Therapy Weekly, February 15th, 2001

- by Michelle Marble, staff medical writer -- A combination of electrochemotherapy with cytokine gene transfer resulted in long-term antitumor immunity in a murine B16 melanoma model, a recent study showed.

"When cancer cells, including melanoma cells, are genetically altered to secrete cytokines, irradiated, and injected into subjects, long-term antitumor immunity is induced," wrote L. Heller and colleagues, University of South Florida, Tampa. "Optimally, existing melanomas induced to produce cytokines in vivo could stimulate this same immune response."

Heller et al. published their study in the journal Melanoma Research ("In vivo...

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Source: Gene Therapy Weekly (2001-02-15)

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