Antisense Gene Therapy
IGF-I Triple-Helix Induces Immunological Changes in Cancer Cells
Published in Gene Therapy Weekly, February 15th, 2001
"IGF-I antisense gene therapy has been applied successfully to animal models of glioma, hepatoma, and teratocarcinoma," wrote A. Ly and colleagues, University of Paris. "The antisense strategy has shown that tumor cells transfected with vectors encoding IGF-I antisense RNA lose tumorigenicity, become immunogenic, and are associated with tumor-specific immune response involving CD8+ lymphocytes."
Ly et al. published their study in the journal Life...
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Source: Gene Therapy Weekly (2001-02-15)
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