Published in Gene Therapy Weekly, February 22nd, 2001
"Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy," wrote X.Y. Zheng and colleagues, Huddinge University Hospital. "We have recently cloned a multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK), and we have shown that the enzyme phosphorylates cytotoxic pyrimidine and purine nucleoside analogs."
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