Cancer Gene Therapy
Suicide Potential of Fruitfly Nucleoside Kinase Explored
Published in Gene Therapy Weekly, February 22nd, 2001
"Nucleoside kinases from several species are investigated as suicide genes for treatment of malignant tumors by combined gene/chemotherapy," wrote X.Y. Zheng and colleagues, Huddinge University Hospital. "We have recently cloned a multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster (Dm-dNK), and we have shown that the enzyme phosphorylates cytotoxic pyrimidine and purine nucleoside analogs."
Zheng et al. published their study in the Journal of Biological Chemistry ("Retroviral transduction of cancer cell...
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Source: Gene Therapy Weekly (2001-02-22)
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