Published in Gene Therapy Weekly, February 22nd, 2001
"The use of hepatocytes for gene therapy is limited by the difficulty of maintaining and altering primary liver cells in culture," wrote K.J. Allen and colleagues, Royal Children's Hospital, Victoria. "A conditionally immortalized mouse hepatocyte cell line has been developed which can be passaged indefinitely at the permissive temperature (33(degree)C), but fails to proliferate and dies at the non-permissive temperature (39(degree)C) in vitro."
Allen et al. published their study in the Journal of Gastroenterology...
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