Disease Associations

"Missing Link" Found Between Rare Disease And Inherited Forms Of Breast Cancer

Published in Gene Therapy Weekly, March 8th, 2001

Scientists following the gene trail of one of the world's rarest diseases have found it leads to an entirely unexpected place: to BRCA1, a gene that, when defective, is the most common source of inherited breast cancer.

In two studies published in the February 2001 issue of Molecular Cell, researchers led by Alan D'Andrea, MD, of Dana-Farber Cancer Institute, Boston, Massachusetts, show how genes involved in a condition called Fanconi anemia form a "pathway" to the activation of BRCA1. If BRCA1 or any of the Fanconi genes are abnormal, the risk of cancer increases dramatically.

"There's strong evidence that under normal conditions, BRCA1...

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Source: Gene Therapy Weekly (2001-03-08)

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