Gene Transfer
Pharmacodynamic Approach Determines Potency And Efficacy
Published in Gene Therapy Weekly, March 8th, 2001
"In the present work we set out to apply pharmacodynamic concepts derived from dose-response curves (potency and efficacy) to characterize the gene transfer efficiency of a vector:DNA complex," said S.F. Alino and colleagues, University of Valencia. "We employed two widely-used vectors, the cationic lipid DOTAP (N,N,N-trimethyl 1-2-3-bis (1-oxo-9-octadecenyl)oxy (Z,Z)-1-propanaminium methyl sulfate) and the cationic polymer PEI (polyethylenimine, 800 kDa) to transfect several constructions of the green fluorescent...
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Source: Gene Therapy Weekly (2001-03-08)
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