Cancer Gene Therapy

Some Tumor Cells Survive Oxygen Deprivation, Then Thrive When Re-Oxygenated

Published in Gene Therapy Weekly, March 15th, 2001

by Sonia Nichols, staff medical writer -- Survival of the fittest appears to be the best way to describe tumor cells that survive oxygen deprivation, then begin to proliferate after re-oxygenation.

In some instances, oxygen-deprived cells continued to grow even when levels of the tumor inhibition gene p53 increased, according to investigators.

"In solid tumors hypoxia and re-oxygenation may be important factors in secondary expansion after anti-cancer therapy," said Manabu Kinoshita and colleagues at Hamamatsu Air Base in Shizuoka and Stanford University School of Medicine in California.

They subjected cells from a...

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Source: Gene Therapy Weekly (2001-03-15)

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