Published in Gene Therapy Weekly, April 12th, 2001
Use of recombinant adenoviral vectors for delivery of tissue-specific transgenes is an important protocol in gene therapy. Therapeutic genes are commonly inserted within the E1A gene of the adenoviral genome. Researchers have found, however, that genes expessed from within this site tend to lose tissue-specific promoter regulation.
S. Rubinchik and colleagues...
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