Published in Gene Therapy Weekly, April 19th, 2001
TNF(alpha) is cytotoxic to tumor cells, however high doses of TNF(alpha) can be damaging to normal tissues. In a previous report, F. Bazzoni and colleagues reported that the M-r 55,000 TNF receptor could induce apoptosis in the absence of TNF(alpha).
In their current study, Bazzoni et al. placed the TNF receptor under the control of a melanoma specific promoter/enhancer element and cloned the construct into a replication deficient adenovirus vector. ...
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