Scirrhous Gastric Cancer

Gene Expression Analyzed In Tumor Cell Lines With Metastatic Potential

Published in Gene Therapy Weekly, April 19th, 2001

by Deborah W. Heinrich, staff medical writer - Researchers at the University of Tokyo in Japan used high density oligonucleotide array analysis to examine gene expression in scirrhous gastric cancer cell lines.

Scirrhous gastric cancer has the highest mortality rate among gastric cancers due to its high potential for metastasis to the peritoneum and lymph nodes. To investigate the genes involved in the many steps leading to metastasis, Y. Hippo and colleagues conducted global analysis on differential expression of genes in the scirrhous gastric cancer cell line OCUM-2M and its sublines OCUM-2MD3 and OCUM-2MLN, which have high potential for metastasis to the peritoneum...

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Source: Gene Therapy Weekly (2001-04-19)

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