Published in Gene Therapy Weekly, April 19th, 2001
The research, described in the April 4, 2001, issue of Gene Therapy, shows that the cloned promoter of the human telomerase reverse transcriptase (hTERT) gene can drive the selective expression of therapeutic genes in cancer cells in vitro and in vivo, while remaining inactive in normal somatic cells and tissues.
The research takes advantage of the fact that hTERT is expressed in essentially all human cancers, in which it functions to maintain the...
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