Gene Delivery

F-PE Enhances In Vivo Liposomal Gene Transfer To Mouse Lungs

Published in Gene Therapy Weekly, May 24th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Two studies in the March-April 2001 issue of the Journal of Gene Medicine focus on lipid-mediated gene delivery.

Researchers have found viral vectors deliver therapeutic genes with greater efficiency than do synthetic vectors. In order to improve the efficiency of synthetic liposomal gene delivery vectors, cationic polymers have been added to lipoplex preparations. Dioleoyl-L-alpha-phosphatidyl-ethanolamine, or DOPE, is a helper lipid broadly used in lipoplex preparation. In previous studies, B. Mui et al. determined that DOPE improved gene delivery via fusogenic properties, allowing DNA transfer to occur by...

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Source: Gene Therapy Weekly (2001-05-24)

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