Published in Gene Therapy Weekly, May 24th, 2001
Researchers have found viral vectors deliver therapeutic genes with greater efficiency than do synthetic vectors. In order to improve the efficiency of synthetic liposomal gene delivery vectors, cationic polymers have been added to lipoplex preparations. Dioleoyl-L-alpha-phosphatidyl-ethanolamine, or DOPE, is a helper lipid broadly used in lipoplex preparation. In previous studies, B. Mui et al. determined that DOPE improved gene delivery via fusogenic properties, allowing DNA transfer to occur by...
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