Vector Development
The HSV Structural Protein VP22 Enhances Thymidine Kinase Cytotoxicity
Published in Gene Therapy Weekly, May 24th, 2001
by Deborah W. Heinrich, PhD, staff medical writer - Herpes simplex virus thymidine kinase (TK) is a suicide gene used in cancer gene therapy. Upon transfection, it renders cells susceptible to the drug gancyclovir (GCV). Unfortunately, researchers at Prince Charles Hospital in Australia report that TK/GCV usefulness in the clinical setting is limited by inefficient gene delivery necessitating toxic levels of GCV to induce cytotoxicity.
To improve cytotoxicity while reducing concentrations of GCV to therapeutic levels, C. Liu and colleagues took advantage of the herpes simplex virus-1 structural protein, VP22, and its ability to improve cellular trafficking.
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Source: Gene Therapy Weekly (2001-05-24)
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