Gene Delivery

A Novel DNAse-II Inhibitor Enhances Gene Delivery

Published in Gene Therapy Weekly, May 24th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Non-viral lipid-mediated gene transfer for the purpose of delivering therapeutic genes has been improved by incorporating cationic fusogenic polymers, such as dioleoyl-L-alpha -phosphatidyl-ethanolamine (DOPE) and partially fluorinated glycerophosphoethanolamine (F-PE) as well as by complexing DNA with the cationic polymer polyethylenimine (PEI).

Once these complexes deliver genes to endosomes and DNA condensing agents are shed, however, DNA is exposed to DNases, which may limit concentrations available for nuclear transport and subsequent transgene expression, suggest H. Pollard and colleagues in an article...

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Source: Gene Therapy Weekly (2001-05-24)

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