Cancer Therapy

Photosensitizers Enhance Lysosomal Release Of Transgenes

Published in Gene Therapy Weekly, June 7th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Photodynamic therapy uses chemicals to make cells more receptive to anticancer treatment. Researchers in Norway report a novel technology, photochemical internalization, that could improve transgene expression.

L. Prasmickaite and colleagues in the Department of Biophysics at the Institute for Cancer Research at Norwegian Radium Hospital in Montebello, Norway are using photosensitizers to aid transgene release from endocytic vesicles.

With photodynamic therapy (PDT), the simultaneous presence of light, usually from a laser source, and a photosensitizer are thought to result in photo-oxidation, or...

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Source: Gene Therapy Weekly (2001-06-07)

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