Gene Delivery

Beta-Cyclodextrin-Based Polymers Are Promising Transfection Vectors

Published in Gene Therapy Weekly, June 7th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Researchers at Caltech in Pasadena, California, have fine-tuned a polymer for gene delivery that could prove to be more efficient and have fewer side effects.

S.J. Hwang and colleagues are working on improving linear cationic beta-cyclodextrin-based polymers (beta CDPs). "The beta CDPs are synthesized by the condensation of a diamino-cyclodextrin monomer A with a diimidate comonomer B," they explained.

To determine the most effective lipoplex structure composed of beta CDPs, Hwang and coworkers compared transfection efficiency and toxicity between different polymers in vitro.

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Source: Gene Therapy Weekly (2001-06-07)

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