Wound Healing

Transgenes Can Be Expressed In Scalded Skin

Published in Gene Therapy Weekly, June 7th, 2001

University of Michigan, Ann Arbor, researchers are applying gene therapy techniques to injured skin, which provides an ideal model for identifying and tracking transgene expression.

L. Steinstraesser and coworkers used particle-mediated gene transfer to introduce reporter genes to burned skin. In an animal model, water burns at 60(degree)C were administered for 10, 20, or 40 seconds. Ten-second scalds were considered superficial, partial thickness burns, 20-second scalds were categorized as deep partial thickness burns, and 40-second scalds were full thickness burns.

The reporter gene beta-galactosidase was administered via gene gun to the damaged...

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Source: Gene Therapy Weekly (2001-06-07)

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