Published in Gene Therapy Weekly, June 21st, 2001
P.B. Robbins and colleagues in the Program of Epithelial Biology at Stanford University School of Medicine in Stanford, California explained that skin blistering and an altered distribution of basement membrane zone proteins such as BPAG2, integrins beta4/beta1, and laminins alpha3/gamma2 observed in patients with JEB are a result of mutation in the laminin 5 beta 3 gene, LAMB3. They therefore hypothesized that wild type expression of LAMB in keratinocytes in these patients might ameliorate...
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