Safety Issues

Adenovirus Vectors Cannot Infect Female Germ-Line Cells

Published in Gene Therapy Weekly, June 28th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - The risk of female germ-line infection with adenovirus during gene therapy is low, according to research in the United States.

An important concern facing implementation of gene therapy protocols in humans is the potential of adenovirus infection of oocytes which could pass along potentially unwanted genetic alterations to future generations. J.W. Gordon, Mt. Sinai School of Medicine, New York City, assessed this risk in female mouse germ-line cells and reported the findings in Molecular Therapy.

In the first set of experiments, Gordon constructed a recombinant adenovirus vector expressing...

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Source: Gene Therapy Weekly (2001-06-28)

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