Published in Gene Therapy Weekly, July 5th, 2001
H. Kishioka and colleagues in the University's Department of Internal Medicine noticed that PDGF A-chain mRNA levels in aortas and kidneys of stroke-prone spontaneous hypertensive rats (SHR-SP) were higher than in nonhypertensive Wistar-Kyoto rats. This led them to speculate that inhibition of PDGF A-chain translation might improve organ damage in hypertensive rats.
They constructed a phosphorothiolate-linked 15mer antisense...
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