Hypertension

Antisense PDGF Therapy Improves Organ Damage In Rats

Published in Gene Therapy Weekly, July 5th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Researchers at Nihon University in Tokyo improved arterial and renal tissue damage in hypertensive rats with antisense platelet-derived growth factor (PDGF) A-chain therapy.

H. Kishioka and colleagues in the University's Department of Internal Medicine noticed that PDGF A-chain mRNA levels in aortas and kidneys of stroke-prone spontaneous hypertensive rats (SHR-SP) were higher than in nonhypertensive Wistar-Kyoto rats. This led them to speculate that inhibition of PDGF A-chain translation might improve organ damage in hypertensive rats.

They constructed a phosphorothiolate-linked 15mer antisense...

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Source: Gene Therapy Weekly (2001-07-05)

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