Fibrosis
Antisense Transcription Factor Sp1 Downregulates Extracellular Matrix Genes
Published in Gene Therapy Weekly, July 26th, 2001
According to F. Verrecchia and colleagues, Hopital St. Louis, Paris, "Fibrosis is a consequence of injury characterized by accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of normal tissue architecture and loss of function."
Therefore, the transcription factor Sp1, which regulates the basal expression of various extracellular matrix genes, might play an important role in the development of fibrosis. Verrecchia and coworkers evaluated the effects of antisense Sp1...
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Source: Gene Therapy Weekly (2001-07-26)
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