Cancer Therapies

Tumor Growth Halted By Manipulating Telomerase Enzyme

Published in Gene Therapy Weekly, August 9th, 2001

University of California, San Francisco, researchers report that they were able to slow the growth of human cancer cells, or cause them to commit suicide altogether, by creating just a miniscule mutation in the telomerase enzyme.

The study, conducted in breast and prostate cells grown in culture and in tumors formed from human breast cancer cells grafted into mice, suggests that human cancer cells are much more sensitive to disruptions in the telomerase enzyme than had been thought. The finding hints, the researchers say, at a possible new strategy for thwarting human cancers.

In humans, telomerase is inactive in most adult cells, and only active at...

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Source: Gene Therapy Weekly (2001-08-09)

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