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Myocardial Infarction

Novel Cardiac Gene Expression Activator Identified

Published in Gene Therapy Weekly, August 9th, 2001

Collateral Therapeutics, Inc. (CLTX) announced that researchers at the University of Texas Southwestern Medical Center at Dallas (UT Southwestern) identified a novel cardiac-specific gene expression activator for use in Collateral's heart muscle regeneration program.

In preclinical studies published in the June 29, 2001, issue of Cell, Eric N. Olson, PhD, chairman of the molecular biology department at UT Southwestern, showed that a novel and highly potent transcription factor called Myocardin is expressed specifically in cardiac and smooth muscle cells and is capable of up-regulating a number of cardiac-specific genes in non-muscle cells.

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