Glioma

Caspase-9 Expression Can Override Resistance To p53-Mediated Apoptosis

Published in Gene Therapy Weekly, September 6th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - New evidence published in Neurosurgery suggests that caspase-9 can override glioma cell resistance to apoptosis in response to p53 gene therapy.

Since gliomas tend to differ in their susceptibility to p53-mediated apoptosis, success with p53 gene therapy is not consistent. Therefore, N. Shinoura and colleagues at the Tokyo Metropolitan Komagome Hospital in Tokyo, Japan designed an experiment in which a downstream effector of p53-induced apoptosis was used for gene therapy instead of p53. This downstream effector was caspase-9 and its gene was encoded on a recombinant adenovirus vector and transfected into...

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Source: Gene Therapy Weekly (2001-09-06)

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