Published in Gene Therapy Weekly, September 6th, 2001
Since gliomas tend to differ in their susceptibility to p53-mediated apoptosis, success with p53 gene therapy is not consistent. Therefore, N. Shinoura and colleagues at the Tokyo Metropolitan Komagome Hospital in Tokyo, Japan designed an experiment in which a downstream effector of p53-induced apoptosis was used for gene therapy instead of p53. This downstream effector was caspase-9 and its gene was encoded on a recombinant adenovirus vector and transfected into...
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