Published in Gene Therapy Weekly, September 6th, 2001
Chronic inflammation is mediated by macrophages and neutrophils that migrate from the bone marrow, liver, and spleen to inflamed tissues. T. Yokoo and colleagues at Jikei University in Tokyo postulated that long-term damage of this sort might be alleviated if the bone marrow could be repopulated with anti-inflammatory stem cells. In order to achieve this, they genetically altered donor stem cells from male mice to secrete an interleukin-1 (IL-1) agonist (IL-1Ra) using...
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