Chronic Inflammation

Transplantation Of Genetically Altered Stem Cells Retarded Morbidity

Published in Gene Therapy Weekly, September 6th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Researchers in Japan demonstrated that chronic inflammation can be treated by transplantation of genetically altered anti-inflammatory stem cells.

Chronic inflammation is mediated by macrophages and neutrophils that migrate from the bone marrow, liver, and spleen to inflamed tissues. T. Yokoo and colleagues at Jikei University in Tokyo postulated that long-term damage of this sort might be alleviated if the bone marrow could be repopulated with anti-inflammatory stem cells. In order to achieve this, they genetically altered donor stem cells from male mice to secrete an interleukin-1 (IL-1) agonist (IL-1Ra) using...

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Source: Gene Therapy Weekly (2001-09-06)

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