Heart Disease

Activation Of Akt Has Cardioprotective Effect After Transient Ischemia

Published in Gene Therapy Weekly, September 20th, 2001

by N.R. Saltmarsh, staff medical writer - Activation of the serine-threonine kinase Akt can reverse some of the effects of transient cardiac ischemia and can preserve undamaged heart cells, according to a new report in Circulation.

"Akt activation reduces cardiomyocyte apoptosis in models of transient ischemia," reported T. Matsui and colleagues at Harvard University School of Medicine. "Its role in cardiac dysfunction or infarction, however, remains unclear."

Matsui and team tested an active Akt mutant (myr-Akt) in rats with cardiac ischemia-reperfusion injury. They found that gene transfer of myr-Akt reduced infarct size by 64% and the...

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Source: Gene Therapy Weekly (2001-09-20)

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