Published in Gene Therapy Weekly, September 20th, 2001
"Akt activation reduces cardiomyocyte apoptosis in models of transient ischemia," reported T. Matsui and colleagues at Harvard University School of Medicine. "Its role in cardiac dysfunction or infarction, however, remains unclear."
Matsui and team tested an active Akt mutant (myr-Akt) in rats with cardiac ischemia-reperfusion injury. They found that gene transfer of myr-Akt reduced infarct size by 64% and the...
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