Published in Gene Therapy Weekly, September 20th, 2001
"The objectives of this study were to prepare BMP-2-expressing muscle-derived cells by transduction of these cells with an adenovirus containing BMP-2 cDNA and to determine whether the BMP-2-expressing muscle-derived cells would elicit the healing of critical-sized bone defects in mice," reported J.Y. Lee and colleagues at Children's Hospital of Pittsburgh.
The researchers transduced primary cultures of muscle-derived cells from a normal male mouse...
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