Blindness

Gene Therapy May Be A Tool For Prevention

Published in Gene Therapy Weekly, October 11th, 2001

Gene therapy may one day be used to halt or even prevent the overgrowth of blood vessels in the eye that blinds patients with macular degeneration and diabetic retinopathy, according to two recent studies led by researchers at Johns Hopkins' Wilmer Eye Institute.

In the studies, performed with laboratory mice, two different genes that were separately injected into the tail veins or eyes of the animals reduced new blood vessel growth by up to 90%. One gene is for endostatin, which inhibits blood vessel growth; the other is a substance that increases cell survival. The mice had conditions similar to macular degeneration and diabetic retinopathy, the leading causes of...

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Source: Gene Therapy Weekly (2001-10-11)

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