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Tuberculosis Therapy

Genetic Analysis May Not Be Sufficient For Drug-Resistance Testing

Published in Gene Therapy Weekly, October 11th, 2001

by Michael Greer, senior medical writer - Tuberculosis gene analysis may not provide enough information to diagnose drug-resistant strains, researchers in South Africa warn.

"The use of pyrazinamide (PZA) is important for the treatment of Mycobacterium tuberculosis as it is bactericidal to semi-dormant mycobacteria that are not affected by other drugs," explained K.S. Bishop and colleagues at the University of Natal in Durban and the SAIMR Tuberculosis Reference Laboratory in Gauteng. However, "incidence of resistance to PZA and other drugs used in the treatment of M. tuberculosis is increasing in South Africa."

Although genetic...

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