Tumor Therapy

Antisense Strategy Dampens Angiogenesis, Promotes Apoptosis In Neoplasms

Published in Gene Therapy Weekly, October 11th, 2001

by Sonia Nichols, senior medical writer - The authors of an Italian study suggest use of antisense technology to destroy mitogenic signaling and to prohibit the expression of antiapoptotic genes might pack a powerful punch against cancer.

"We and others have recently shown that a novel class of mixed-backbone oligonucleotides targeting the protein kinase A type I (PKAI) subunit of RI alpha exhibits improved pharmacokinetic properties and antitumor activity accompanied by increased apoptosis in several human cancer types in vitro and in vivo," remarked G. Tortora and colleagues, University of Naples Federico II, in Clinical Cancer Research.

The...

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Source: Gene Therapy Weekly (2001-10-11)

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