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Leukemia

Quantitative Wilms Tumor Gene Useful For Disease Monitoring

Published in Gene Therapy Weekly, October 18th, 2001

by Michael Greer, senior medical writer - A real-time method for measuring oncogene levels may be useful for monitoring disease activity in leukemia patients, according to researchers in Germany.

"The Wilms tumor gene (WT1) has been suggested as a powerful parameter for molecular monitoring of minimal residual disease (MRD) in leukaemias," explained Dr. Christian Andreas Schmidt and colleagues at Humboldt University in Berlin. However, the "complex and inaccurate" methods used to determine WT1 levels have discouraged routine monitoring, they noted.

Schmidt and coworkers found that real-time, quantitative molecular monitoring of WT1 is feasible using...

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