Vaccine Delivery

Coimmunization Leads To Immune Response In Woodchuck Hepatitis Model

Published in Gene Therapy Weekly, October 25th, 2001

by Sonia Bell-Nichols, senior medical writer - Coimmunization with plasmids encoded for interleukin (IL)-12 appears to boost Th1 cytokine response and protective immunity in animals vaccinated with the core antigen of woodchuck hepatitis virus (WHV), which closely resembles hepatitis B virus (HBV).

Although animal vaccination with plasmids encoded for woodchuck hepatitis core antigen (pCw) stimulates the production of antigen-specific T cells, those cells produce insufficient levels of interferon (IFN)-(gamma) and do not effect viral immunity, the authors of a new study say. By coimmunizing animals with vectors containing IL-12, they have overcome that problem,...

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Source: Gene Therapy Weekly (2001-10-25)

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