Kidney Disease

Study Defines Pathway Involved In Glucose-Associated Diabetic Nephropathy

Published in Gene Therapy Weekly, November 22nd, 2001

by Sonia Nichols, senior medical writer - Scientists believe they have found the major biochemical pathway associated with diabetic glomerulopathy, a significant complication of diabetes.

Citing recent studies that show an important interrelationship among cellular metabolism, high glucose (HG) levels, and the hexosamine biosynthesis pathway (HBP), researchers at the University of Mississippi described how they determined the importance of the role of HBP in relation to cells of the mesangium in diabetic glomerulopathy.

"In this study, we investigated the role of HBP on HG-stimulated fibronectin protein synthesis, a matrix component, in...

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Source: Gene Therapy Weekly (2001-11-22)

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