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Alzheimer Disease

Protein Insight Could Lead To Treatment

Published in Gene Therapy Weekly, December 27th, 2001

A protein linked to accumulation of harmful brain plaque in Alzheimer patients has been shown in fruit flies and mice to be an important part of a molecular transportation system that moves signals and vital protein cargoes within the brain.

In addition, researchers have determined that the protein, called amyloid precursor protein (APP), can induce a biochemical process that clogs brain traffic lanes and eventually leads to neuron cell death.

The findings are the first scientific data that describe the transport role of APP and that offer a new hypothesis linking the protein's cellular trafficking function to the formation of harmful plaque deposits...

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