Vaccine Adjuvants
Transduced Dendritic Cells Inspire Antitumor Effect
Published in Gene Therapy Weekly, January 10th, 2002
"Gene delivery to dendritic cells provides an intracellular source of antigen for efficient and persistent loading to MHC class I molecules capable of activating CD8+ CTLs, which play a central role in antitumor immunity," N. Okada and colleagues, Kyoto Pharmaceutical University, Japan, described in a recent report.
To date, attempts at efficient dendritic cell transduction have met with many failures and some successes. Okada and colleagues have performed research suggesting the...
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Source: Gene Therapy Weekly (2002-01-10)
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