Pulmonary Edema

Vector-Mediated Receptor Overexpression Clears Fluids In Rodent Lungs

Published in Gene Therapy Weekly, January 17th, 2002

by Sonia Nichols, senior medical writer - An Illinois research team has established that gene therapy can be used to enhance the responsiveness of distressed pulmonary tissues to endogenous catecholamines, resulting in reduced edema in rodent models.

The same treatment might be useful for clearing alveolar fluid from the lungs of humans, they proposed in a recent edition of Circulation Research.

"Adenoviral-mediated overexpression of a human beta (2)-adrenergic receptor (beta (2)AR) cDNA increases beta (2)AR mRNA, membrane-bound receptor protein expression, and receptor function (procaterol-induced cAMP production) in human lung epithelial...

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Source: Gene Therapy Weekly (2002-01-17)

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