Xenotransplantation

First Cloned Knock-Out Pigs Born Christmas Day

Published in Gene Therapy Weekly, January 24th, 2002

PPL Therapeutics, plc, announced it has produced knock-out piglets that were born as a result of using nuclear transfer (cloning) and PPL's patented gene targeting technology.

The five healthy births took place on December 25, 2001. It has always been the objective of PPL's xenotransplantation program to produce knock-out pigs. In the future, this vital step should enable organs and/or cells from such animals to be transplanted into humans and not be rejected by the human recipient.

In knock-out pigs scientists have inactivated the specific gene that leads to the human immune system's rejecting pig organs.

The announcement...

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Source: Gene Therapy Weekly (2002-01-24)

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