Gene Targeting
Caveolin-1 Promoter Drives Gene Therapy To Reduce Prostate Malignancy Size
Published in Gene Therapy Weekly, January 24th, 2002
"Caveolin-1, a structural component of caveolae, is overexpressed in metastatic and androgen-resistant prostate cancer and highly expressed in tumor-associated endothelial cells," Christina Pramudji and coworkers said of its role in prostatic malignancies. Pramudji and colleagues at Baylor College of Medicine in Houston, Texas, worked with associates at the Veterans Affairs Medical Center, also in Houston, to study the effects of gene signaling on prostate cancer cells growing in vivo and in vitro.
Pramudji and team, placing the cav-1 promoter upstream of a herpes simplex virus (HSV)-tk gene in an adenovirus vector (Adcav-1tk), also created similar...
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Source: Gene Therapy Weekly (2002-01-24)
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